Show
Table step 1 suggests the fundamental attributes of one’s ten,798 players who’d done advice about NHANES 1999–2004 research. Of these players, dos,123 (19.7%) got migrainepared in order to non-horror, horror was indeed more likely to getting more youthful, lady, non-Latina Black, previous consuming, most recent puffing, possess straight down studies height, all the way down incidence regarding blood pressure, higher Body mass index, higher carbohydrate intake, straight down calcium supplements and you will magnesium intake, and lower nutritional D enhance intake. The typical every day intake off calcium supplements and you will magnesium is somewhat down than simply their particular required fat loss allowances (RDAs), due to the fact revealed when you look at the Desk dos.
Table 3 shows a significant inverse association between dietary calcium and magnesium intake and migraine after adjusting for the possible confounders. The ORs (95% CI) for the association between dietary calcium intake and migraine were 0.85 (0.73–0.99) and 0.77 (0.63–0.93), comparing the Q2 (– mg/day) and Q5 (?1, mg/day) quintile of calcium with the lowest quintile (? mg/day), respectively. The ORs (95% CI) of Q2 (– mg/day), Q3 (– mg/day), Q4 (– mg/day), and Q5 (? mg/day) quintile of magnesium were 0.81 (0.69–0 sito web incontri lesbiche.95), 0.83 (0.70–0.98), 0.78 (0.65–0.94), and 0.69 (0.55–0.86) compared with Q1 (< mg/day).
Immediately following stratifying by the gender, the brand new connection between your high as well as the reduced quintile regarding calcium supplements intake and you may migraine stayed mathematically high in women and guys. To possess losing weight magnesium, this new Or (95% CI) is actually 0.62 (0.47–0.83), comparing the highest (? mg/d) while the lower quintile (? mg/d) away from magnesium intake in females. Although not, there can be zero mathematically high relationship anywhere between fat reduction magnesium intake and you will migraine when you look at the males (Profile step 1).
Contour 1. Studies was basically displayed while the Otherwise (95% CI). Restrict lines imply 95% CI. ORs were adjusted to have age, race/ethnicity, smoking, taking, relationship, studies top, Body mass index, energy consumption, protein intake, carb intake, calcium complement, magnesium complement, vitamin D enhance, hypertension, diabetic issues, heart attack, coronary heart state, C activated necessary protein, and you will total cholesterol.
We also examined the potential correlation and joint association between calcium and magnesium. We found that calcium and magnesium were highly correlated (r = 0.631; P < 0.001) (data are not shown). We divided participants into four groups based on the quintile intake of calcium and magnesium, after adjusting for potential confounders, joint analyses showed that the OR (95% CI) of migraine in the high-calcium and high-magnesium group was 0.77 (0.64–0.91) compared with the low-calcium and low-magnesium group. After stratifying by sex, the joint association of dietary calcium and magnesium remained significant in women. However, the joint association was not significant in men (Table 4).
In RCS, we observed a non-linear relationship between calcium and magnesium (continuously measured) and migraine. Significantly decreased ORs (<1.00) were observed when calcium intake ranged from 670 to 1,700 mg/day. The ORs decreased with increasing dietary magnesium levels and were significantly lower than 1.00 when dietary magnesium intake was higher than 243 mg/day (Figure 2).
Contour 2. Relationship between slimming down (A) calcium supplements and you can (B) magnesium intake and you will nightmare in the RCS. New design are adjusted having decades, sex, race/ethnicity, puffing, taking, relationship, training level, Bmi, times consumption, healthy protein consumption, carbohydrate intake, calcium enhance, magnesium enhance, nutritional D enhance, hypertension, diabetes, coronary arrest, cardiovascular state, C reactive healthy protein, and complete cholesterol. Good line, OR; colors, 95% CI.
Conversation
Inside high cross-sectional analysis, i seen an inverse connection ranging from weight-loss calcium and magnesium and you may migraine, independent from extreme confounders. Subgroup study showed that calcium supplements and you can magnesium stayed inversely regarding the migraine in women, correspondingly. For men, simply large dieting calcium consumption is negatively linked to migraine, however, discover zero statistically extreme organization anywhere between dietary magnesium consumption and you will migraine. Additionally, within the considering this new mutual negative effects of calcium supplements and magnesium, i discovered that higher-calcium and highest-magnesium consumption is inversely regarding the migraine in females, consistent with all of our study of the fresh separate negative effects of calcium and you may magnesium.